Publications and Research

Dr. Raher conducted research at the Anesthesia Center for Critical Care Research in the Department of Anesthesia and Critical Care at Massachusetts General Hospital, affiliated with Harvard Medical School.

His work focused on nitric oxide signaling, hemoglobin-based oxygen carriers, cardiac echocardiography, and metabolic physiology.

Nitric Oxide and Hemoglobin-Based Oxygen Carriers

Yu B, Raher MJ, Volpato GP, Bloch KD, Ichinose F, Zapol WM. Inhaled Nitric Oxide Enables Artificial Blood Transfusion Without Hypertension. Circulation. 2008;117(15):1982-1990. PubMed

Yu B, Shahid M, Egorina EM, Sovershaev MA, Raher MJ, Lei C, Wu MX, Bloch KD, Zapol WM. Endothelial Dysfunction Enhances Vasoconstriction Due to Scavenging of Nitric Oxide by a Hemoglobin-based Oxygen Carrier. Anesthesiology. 2010;112(3):586-594.

Cardiac Imaging and Remodeling

Raher MJ, Thibault H, Poh KK, Liu R, Halpern EF, Derumeaux G, Ichinose F, Zapol WM, Bloch KD, Picard MH. In Vivo Characterization of Murine Myocardial Perfusion With Myocardial Contrast Echocardiography. Circulation. 2007;116(11):1250-1257.

Neilan TG, Blake SL, Ichinose F, Raher MJ, Buys ES, Jassal DS, Furutani E, Perez-Sanz TM, Graveline AR, Janssens S, Picard MH, Scherrer-Crosbie M, Bloch KD. Disruption of Nitric Oxide Synthase 3 Protects Against Cardiac Injury, Dysfunction, and Mortality Induced by Doxorubicin. Circulation. 2007;116(5):506-514.

Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Cardiomyocyte-restricted Restoration of Nitric Oxide Synthase 3 Attenuates Left Ventricular Remodeling After Chronic Pressure Overload. American Journal of Physiology: Heart and Circulatory Physiology. 2009.

Kurtz B, Thibault H, Raher MJ, Popovich JR, Cawley SM, Atochin DN, Hayton SR, Shakartzi HR, Huang PL, Bloch KD, Buys ES, Scherrer-Crosbie M. Nitric Oxide Synthase 3 Deficiency Limits Adverse Ventricular Remodeling After Pressure Overload in Insulin Resistance. American Journal of Physiology: Heart and Circulatory Physiology. 2011.

Pulmonary Hypertension

Thibault H, Kurtz B, Raher MJ, Shaik RS, Waxman AB, Derumeaux G, Halpern EF, Bloch KD, Scherrer-Crosbie M. Noninvasive Assessment of Murine Pulmonary Arterial Pressure. Circulation: Cardiovascular Imaging. 2010;3(2):157-163.

Weng M, Raher MJ, Leyton P, Combs TP, Scherer PE, Bloch KD, Bhatt D. Adiponectin Decreases Pulmonary Arterial Remodeling in Murine Models of Pulmonary Hypertension. American Journal of Respiratory Cell and Molecular Biology. 2011.

Brown Adipose Tissue

Baron DM, Clerte M, Brouckaert P, Raher MJ, Flynn A, Zhang H, Carter EA, Picard MH, Bloch KD, Buys ES, Scherrer-Crosbie M. In Vivo Noninvasive Characterization of Brown Adipose Tissue Blood Flow by Contrast Ultrasound in Mice. Circulation: Cardiovascular Imaging. 2012;5(5):652-659.

Clerte M, Baron DW, Brouckaert P, Ernande L, Raher MJ, Flynn A, Picard MH, Bloch KD, Buys ES, Scherrer-Crosbie M. Brown Adipose Tissue Blood Flow and Mass in Obesity: A Contrast Ultrasound Study in Mice. Journal of the American Society of Echocardiography. 2013;26(12):1465-1473.

Hypertension and Guanylate Cyclase

Buys ES, Raher MJ, Kirby A, Mohd S, Baron DW, Hayton SR, Tainsh LT, Sips P, Rauwerdink KM, Yan Q, Tainsh RE, Shakartzi HR, Stevens C, Decaluwe K, Rodrigues-Machado MG, Malhotra R, Van de Voorde J, Wang T, Brouckaert P, Daly MJ, Bloch KD. Genetic Modifiers of Hypertension in Soluble Guanylate Cyclase a1-Deficient Mice. The Journal of Clinical Investigation. 2012;122(6):2316-2325.

Buys ES, Sips P, Vermeersch P, Raher MJ, Rogge E, Ichinose F, Dewerchin M, Bloch KD, Janssens S, Brouckaert P. Gender-specific Hypertension and Responsiveness to Nitric Oxide in sGCa1 Knockout Mice. Cardiovascular Research. 2008;79(1):179-186.

Dordea AC, Vandenwijngaert S, Garcia V, Tainsh RE, Nathan DI, Allen K, Raher MJ, Tainsh LT, Zhang F, Lieb WS, et al. Androgen-sensitive Hypertension Associated With Soluble Guanylate Cyclase-a1 Deficiency Is Mediated by 20-HETE. American Journal of Physiology: Heart and Circulatory Physiology. 2016;310(10):H1055-H1063.

Inflammatory and Immune Mechanisms

Buys ES, Cauwels A, Raher MJ, Bhatt D, Sips P, Ichinose F, Brouckaert P, Bloch KD. sGCa1b1 Attenuates Cardiac Dysfunction and Mortality in Murine Inflammatory Shock Models. American Journal of Physiology: Heart and Circulatory Physiology. 2009.

Feng Y, Zhao H, Xu X, Buys ES, Raher MJ, Bopassa JC, Thibault H, Scherrer-Crosbie M, Schmidt U, Chao W. Innate Immune Adaptor MyD88 Mediates Neutrophil Recruitment and Myocardial Injury After Ischemia-Reperfusion in Mice. American Journal of Physiology: Heart and Circulatory Physiology. 2008.

Tournoux F, Petersen B, Thibault H, Zou L, Raher MJ, Kurtz B, Halpern EF, Chaput M, Chao W, Picard MH, Scherrer-Crosbie M. Validation of Noninvasive Measurements of Cardiac Output in Mice Using Echocardiography. Journal of the American Society of Echocardiography. 2011.

Complete Publication List

View all publications on PubMed